WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing

pubmed: wnt1 2024-09-04

Summary:

Hypertension induces cardiac fibrotic remodelling characterised by the phenotypic switching of cardiac fibroblasts (CFs) and collagen deposition. We tested the hypothesis that Wnt1-inducible signalling pathway protein-1 (WISP-1) promotes CFs' phenotypic switch, type I collagen synthesis, and in vivo fibrotic remodelling. The treatment of human CFs (HCFs, n = 16) with WISP-1 (500 ng/mL) induced a phenotypic switch (α-smooth muscle actin-positive) and type I procollagen cleavage to an intermediate...

Link:

https://pubmed.ncbi.nlm.nih.gov/38891121/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240904113917&v=2.18.0.post9+e462414

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Exome » pubmed: wnt1

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Authors:

Ze Li, Helen Williams, Molly L Jackson, Jason L Johnson, Sarah J George

Date tagged:

09/04/2024, 11:39

Date published:

06/19/2024, 06:00