The TB Portals: An open-access, web-based platform for global drug-resistant tuberculosis data sharing and analysis

"The TB Portals Program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and IT professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis and backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), of which 976 (75.1%) are multi- or extensively drug resistant, and 38.2%, 51.9%, and 36.3% of cases contain X-ray, CT scan, and genomic data, respectively. The top Mycobacterium tuberculosis lineages represented among collected samples are Beijing, T1, and H3, and SNPs that confer resistance to isoniazid, rifampicin, ofloxacin, and moxifloxacin occur the most frequently. These data and samples have promoted drug discovery efforts and research into genomics and quantitative image analysis to improve diagnostics, while also serving as a valuable resource for researchers and clinical providers. The TB Portals database and associated projects are continually growing, and we invite new partners and collaborations in our initiative. The TB Portals data and their associated analytical and statistical tools are freely available at: https://tbportals.niaid.nih.gov"