RP: CB Study Decides To Scale Down Studies To Replicate | Evolving Science

ab1630's bookmarks 2018-08-12

Summary:

"Many people who follow the progress of science may be aware of the reproducibility problem in the field, today. This involves reporting the findings of one published study as though they form an unimpeachable fact on their own, without testing its conclusions by recreating it. The issue is so severe that some putative treatments have risked being fast-tracked through clinical trials far too early in their development and testing. Furthermore, a lack of replication goes against a central tenet of the scientific method. Accordingly, some initiatives have set out to address the reproducibility crisis....

One of these investigations, intending to act on the results of studies in cancer biology, has hit a major snag. Known as the Reproducibility Project: Cancer Biology (RP: CB), the project was set up with the aim of reproducing 50 trials in cancer biology. This was done in response to some concessions from the pharmaceutical industry about the inability to correctly validate the findings of studies in new or improved therapies.

RP: CB was set up by the Center for Open Science in Charlottesville, Virginia in 2013. It was funded by the Laura and John Arnold Foundation to the tune of just over a million dollars. Initially, the project was estimated to take one year per experiment.

Unfortunately, these ambitious intentions may be less than feasible.

Tim Errington, the RP: CB project leader at COS, now admits that his team has had to scale down the original volume of studies to be replicated. At present, they estimated to be able to validate only 36% of the original trial panel...."

 

Link:

https://www.evolving-science.com/information-communication/scale-down-studies-00752

From feeds:

Open Access Tracking Project (OATP) » ab1630's bookmarks

Tags:

oa.new oa.open_science oa.stem oa.reproducibility oa.medicine oa.biology oa.clinical_trials oa.cos oa.usa oa.arnold_foundation oa.pharma

Date tagged:

08/12/2018, 12:15

Date published:

08/12/2018, 08:17