Effectopedia – An Open Data Project for Collaborative Scientific Research, with the aim of reducing Animal Testing

“One of the key problems in natural science research is the lack of effective collaboration. A lot of research is conducted by scientists from different disciplines, yet cross-discipline collaboration is rare. Even within a discipline, research is often duplicated, which wastes resources and valuable scientific potential. Furthermore, without a common framework and context, research that involves animal testing often becomes phenomenological and little or no general knowledge can be gained from it. The peer reviewed publishing process is also not very effective in stimulating scientific collaboration, mainly due to the loss of an underlying machine readable structure for the data and the duration of the process itself. If research results were more effectively shared and re-used by a wider scientific community – including scientists with different disciplinary backgrounds – many of these problems could be addressed. We could hope to see a more efficient use of resources, an accelerated rate of academic publications, and, ultimately, a reduction in animal testing... Effectopedia is a project of the International QSAR Foundation. Effectopedia itself is an open knowledge aggregation and collaboration tool that provides a means of describing adverse outcome pathways (AOPs)1 in an encyclopedic manner... Using automated notifications when researchers create causal linkage between parts of the pathways, they can simultaneously create a valuable contact with a fellow researcher interested in the same topic who might have a different background or perspective towards the subject. Effectopedia allows creation of live scientific documents which are instantly open for focused discussions and feedback whilst giving credit to the original authors and reviewers involved. The review process is never closed and if new evidence arises it can be presented immediately... The type of knowledge needed in Effectopedia requires a paradigm shift in the way research is conducted: from phenomenological to more hypothesis driven. Instead of testing an individual chemical with results often applicable only in the context of the specific experimental design, Effectopedia is targeted at defining the conditions under which certain knowledge can be transferred to other species, levels of biological organization, exposure routes, exposure durations, chemicals and so on... Many universities in the developing world and in transitional economies are not able to pay the full subscription fees to access published work, which keeps them out of the mainstream up-to-date scientific discussions... The simplest way Effectopedia is envisioned to help in the reduction of unnecessary animal testing is by providing a centralized repository for open, easily searchable access to the existing knowledge... If you come from the chemical, pharmaceutical, flavoring, cosmetics or many other industries, the products your company creates are often subject to regulations. A system like Effectopedia could dramatically reduce the cost for development and registration of new products without compromising your competitive edge... "