The role of the histone methyltransferase SET domain bifurcated 1 during palatal development
pubmed: wnt1 2022-06-23
Summary:
The histone methyltransferase SET domain bifurcated 1 (SETDB1) catalyzes the trimethylation of lysine 9 of histone H3, thereby regulating gene expression. In this study, we used conditional knockout mice, where Setdb1 was deleted only in neural crest cells (Setdb1^(fl/fl,)^(Wnt1-Cre +) mice), to clarify the role of SETDB1 in palatal development. Setdb1^(fl/fl,)^(Wnt1-Cre +) mice died shortly after birth due to a cleft palate with full penetration. Reduced palatal mesenchyme proliferation was...