Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of a dCas9 Ribonucleoprotein Complex

pubmed: wnt1 2022-11-24

Summary:

Stress urinary incontinence (SUI) and pelvic floor disorder (PFD) are common conditions with limited treatment options in women worldwide. Regenerative therapy to restore urethral striated and pelvic floor muscles represents a valuable therapeutic approach. We aim to determine the CRISPR interference-mediated gene silencing effect of the nonviral delivery of nuclease-deactivated dCas9 ribonucleoprotein (RNP) complex on muscle regeneration at the cellular and molecular level. We designed four...

Link:

https://pubmed.ncbi.nlm.nih.gov/35758824/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20221124144854&v=2.17.8

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Exome ยป pubmed: wnt1

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Authors:

Yinwei Chen, Lia Banie, Benjamin N Breyer, Yan Tan, Zhao Wang, Feng Zhou, Guifang Wang, Guiting Lin, Jihong Liu, Lei S Qi, Tom F Lue

Date tagged:

11/24/2022, 14:48

Date published:

06/27/2022, 06:00