Feasibility of Using Real-World Data to Replicate Clinical Trial Evidence | Electronic Health Records | JAMA Network Open | JAMA Network

"Question  What percentage of clinical trials published in high-impact journals in 2017 generated evidence that could feasibly be replicated using observational methods and data sources?

Findings  In this cross-sectional study of 220 clinical trials published in high-impact journals in 2017, only 15% could feasibly be replicated using currently available real-world data sources.

Meaning  This study suggests that, although the increasing use of real-world evidence in medical research presents opportunities to supplement or even replace some clinical trials, observational methods are not likely to obviate the need for traditional clinical trials...."