Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction
pubmed: wnt1 2024-04-17
Summary:
CONCLUSIONS: Taken together, our results demonstrate that β-catenin stabilization through Wnt signaling serves a central role in lipid metabolism in the steatotic liver through up-regulation of fatty acid synthesis via Akt/mTOR signaling. These findings suggest hepatic Wnt signaling may represent a therapeutic strategy in hepatic steatosis.