Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway
pubmed: wnt1 2024-05-20
Summary:
CONCLUSIONS: VitD can further inhibit the nuclear translocation of β-catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt/β-catenin signal pathway.