Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex

pubmed: wnt1 2024-09-04

Summary:

Wnt/Wingless (Wg) signaling is critical in development and disease, including cancer. Canonical Wnt signaling is mediated by β-catenin/Armadillo (Arm in Drosophila) transducing signals to the nucleus, with IFT-A/Kinesin 2 complexes promoting nuclear translocation of β-catenin/Arm. Here, we demonstrate that a conserved small N-terminal Arm^(34)^(-)^(87)/β-catenin peptide binds to IFT140, acting as a dominant interference tool to attenuate Wg/Wnt signaling in vivo. Arm^(34)^(-)^(87) expression...

Link:

https://pubmed.ncbi.nlm.nih.gov/38870008/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240904113917&v=2.18.0.post9+e462414

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Exome » pubmed: wnt1

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Authors:

Linh T Vuong, Marek Mlodzik

Date tagged:

09/04/2024, 11:39

Date published:

06/13/2024, 06:00