The T-box transcription factor Midline regulates wing development by repressing wingless and hedgehog in Drosophila.
pubmed: wnt1 2018-05-01
Summary:
Related Articles The T-box transcription factor Midline regulates wing development by repressing wingless and hedgehog in Drosophila.
Sci Rep. 2016 06 15;6:27981
Authors: Fu CL, Wang XF, Cheng Q, Wang D, Hirose S, Liu QX
Abstract Wingless (Wg) and Hedgehog (Hh) signaling pathways are key players in animal development. However, regulation of the expression of wg and hh are not well understood. Here, we show that Midline (Mid), an evolutionarily conserved transcription factor, expresses in the wing disc of Drosophila and plays a vital role in wing development. Loss or knock down of mid in the wing disc induced hyper-expression of wingless (wg) and yielded cocked and non-flat wings. Over-expression of mid in the wing disc markedly repressed the expression of wg, DE-Cadherin (DE-Cad) and armadillo (arm), and resulted in a small and blistered wing. In addition, a reduction in the dose of mid enhanced phenotypes of a gain-of-function mutant of hedgehog (hh). We also observed repression of hh upon overexpression of mid in the wing disc. Taken together, we propose that Mid regulates wing development by repressing wg and hh in Drosophila.
PMID: 27301278 [PubMed - indexed for MEDLINE]