Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimentalautoimmune myocarditis
pubmed: wnt1 2021-03-04
Summary:
CONCLUSIONS: Ang II-ATR1 signalling is critical for development of postinflammatory fibrotic remodelling and dilated cardiomyopathy. Our data underpins the importance of Ang II-ATR1 in effective TGF-β downstream signalling response including activation of profibrotic Wnt/β-catenin pathway.