Neural Crest-Specific Elp1 Deletion Disrupts Trigeminal Ganglion Development in a Model of Familial Dysautonomia

Neurons in the trigeminal ganglion relay sensory information from the face and oral cavity to the brain. The trigeminal ganglion is unique in its complexity, containing a mixed population of modality-specific (i.e., touch, pain) neurons derived from both neural crest and placodal precursors. The identity of trigeminal ganglion neurons is associated with the expression of Trk neurotrophin receptors, which are required for long-term neuronal function and survival. Within sensory ganglia,...