BQ788 Reveals Glial ETB<sub>R</sub> Modulation of Neuronal Cholinergic and Nitrergic Pathways to Inhibit Intestinal Motility: ETB<sub>R</sub> Signaling is Linked to POI
pubmed: wnt1 2023-06-04
Summary:
CONCLUSION AND IMPLICATIONS: Enteric glial ET-1/ETB(R) signaling provides dual modulation of neural-motor circuits to inhibit motility - It inhibits excitatory cholinergic neural-motor pathways and stimulates inhibitory nitrergic motor pathways. Amplification of glial ETB(R) is linked to muscularis externa inflammation and possibly pathogenic mechanisms of postoperative ileus.