Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Type Report Author Ania Wajnberg Author Fatima Amanat Author Adolfo Firpo Author Deena R. Altman Author Mark J. Bailey Author Mayce Mansour Author Meagan McMahon Author Philip Meade Author Damodara Rao Mendu Author Kimberly Muellers Author Daniel Stadlbauer Author Kimberly Stone Author Shirin Strohmeier Author Viviana Simon Author Judith Aberg Author David L. Reich Author Florian Krammer Author Carlos Cordon-Cardo URL https://science.sciencemag.org/content/early/2020/10/27/science.abd7728 Rights Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Date 28/10/2020 Extra Publisher: American Association for the Advancement of Science Section: Report PMID: 33115920 Institution American Association for the Advancement of Science (AAAS) / Science Library Catalog science.sciencemag.org Language en Abstract SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust IgG antibody responses against the viral spike protein, based on a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City. We also show that titers are relatively stable for at least a period approximating 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggests that more than 90% of seroconverters make detectible neutralizing antibody responses. These titers remain relatively stable for several months after infection.