Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles: A Systematic Review
infodocketGARY's bookmarks 2023-01-27
Question How do preprints of randomized clinical trials (RCTs) on COVID-19 differ from their corresponding published journal articles? Findings In this systematic review of 152 COVID-19 RCT preprints posted in 2021, 119 (78%) were subsequently published in a scientific, peer-reviewed journal. When preprint and journal article pairs were compared, there were differences in terms of outcomes, analyses, results, or conclusions in 65 of 119 studies (55%); however, the main conclusion remained consistent for all but 2 studies (2%). Meaning These findings suggest that although there were differences in the outcomes, analyses, results, or conclusions between RCT preprint and journal article pairs in most cases, the main conclusion remained consistent for the majority of studies.