Scientists regenerate spinal cord in injured rats with stem cells

(credit: Jean-Etienne Minh-Duy Poirrier)

With patches of stem cells on their broken spinal cords, partially paralyzed rats once again reached out and grabbed distant treats, researchers report in Nature Medicine.

While previous studies have shown progress in regenerating certain types of nerve cells in injured spinal cords, the study is the first to coax the regrowth of a specific set of nerve cells, called corticospinal axons. These bundles of biological wiring carry signals from the brain to the spinal cord and are critical for voluntary movement. In the study, researchers were able to use stem cells from rats and humans to mend the injured rodents.

“The corticospinal projection is the most important motor system in humans,” senior author Mark Tuszynski at the University of California, San Diego said. “It has not been successfully regenerated before. Many have tried, many have failed—including us, in previous efforts.”