Founding the Wnt gene family: How wingless was found to be a positional signal and oncogene homolog

pubmed: wnt1 2024-05-26

Summary:

The Wnt family of developmental regulators were named after the Drosophila segmentation gene wingless and the murine proto-oncogene int-1. Homology between these two genes connected oncogenesis to cell-cell signals in development. I review how wingless was initially characterized, and cloned, as part of the quest to identify developmental cell-to-cell signals, based on predictions of the Positional Information Model, and on the properties of homeotic and segmentation gene mutants. The...

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https://pubmed.ncbi.nlm.nih.gov/38214693/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240526114848&v=2.18.0.post9+e462414

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Exome ยป pubmed: wnt1

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Authors:

Nicholas E Baker

Date tagged:

05/26/2024, 11:48

Date published:

01/12/2024, 06:00