Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size

pubmed: wnt1 2024-05-26

Summary:

Skeletal growth, modeling and remodeling are regulated by various molecules, one of them being the recently identified osteoanabolic factor WNT1. We have previously reported that WNT1 transcriptionally activates the expression of Omd, encoding Osteomodulin (OMD), in a murine mesenchymal cell line, which potentially explained the skeletal fragility of mice with mutational WNT1 inactivation, since OMD has been shown to regulate type I collagen fibril formation in vitro. In the present study we...

Link:

https://pubmed.ncbi.nlm.nih.gov/38722812/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240526212558&v=2.18.0.post9+e462414

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Exome » pubmed: wnt1

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Authors:

Wenbo Zhao, Simon von Kroge, Jelena Jadzic, Petar Milovanovic, Praveer Sihota, Julia Luther, Laura Brylka, Felix N von Brackel, Ernesto Bockamp, Björn Busse, Michael Amling, Thorsten Schinke, Timur A Yorgan

Date tagged:

05/26/2024, 21:26

Date published:

05/09/2024, 06:00