Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat

pubmed: wnt1 2024-05-27

Summary:

Physical activity-induced mechanical stimuli play a crucial role in preserving bone mass and structure by promoting bone formation. While the Wnt pathway is pivotal for mediating the osteoblast response to loading, the exact mechanisms are not fully understood. Here, we found that mechanical stimulation induces osteoblastic Wnt1 expression, resulting in an upregulation of key osteogenic marker genes, including Runx2 and Sp7, while Wnt1 knockdown using siRNA prevented these effects. RNAseq...

Link:

https://pubmed.ncbi.nlm.nih.gov/38407813/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240527135329&v=2.18.0.post9+e462414

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Exome ยป pubmed: wnt1

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Authors:

Mubashir Ahmad, Melanie Haffner-Luntzer, Astrid Schoppa, Zeynab Najafova, Teodora Lukic, Timur Alexander Yorgan, Michael Amling, Thorsten Schinke, Anita Ignatius

Date tagged:

05/27/2024, 13:53

Date published:

02/26/2024, 06:00