Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

pubmed: wnt1 2024-07-19

Summary:

Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to the developing proximal aorta and are linked to disease propensity in adults. We analyzed single-cell transcriptomes of SMCs from mature thoracic aortas in mice to determine basal states and changes after disrupting transforming growth factor-β (TGFβ) signaling necessary for aortic homeostasis. A minority of Myh11 lineage-marked SMCs differentially expressed genes suggestive of embryological origin. Additional analyses...

Link:

https://pubmed.ncbi.nlm.nih.gov/38746256/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20240719081414&v=2.18.0.post9+e462414

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Exome » pubmed: wnt1

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Authors:

Pengwei Ren, Bo Jiang, Abdulrahman Hassab, Guangxin Li, Wei Li, Roland Assi, George Tellides

Date tagged:

07/19/2024, 08:15

Date published:

05/15/2024, 06:00