Conditional deletion of IP<sub>3</sub>R1 by Islet1-Cre in mice reveals a critical role of IP<sub>3</sub>R1 in interstitial cells of Cajal in regulating GI motility
pubmed: wnt1 2024-12-21
Summary:
CONCLUSIONS: IP(3)R1 deletion in both ICCs and SMCs but not in SMCs alone causes an IPO phenotype, suggesting that IP(3)R1 in ICCs plays an essential role in regulating GI motility in vivo.