Activating Wnt1/beta-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain
pubmed: wnt1 2025-03-25
Summary:
Parkinson's disease (PD) is the world's second most prevalent neurodegenerative disease. Currently, aside from levodopa, there are no other effective drugs clinically available to slow its progression. Otx2 plays a critical role in the differentiation of midbrain dopaminergic neurons (mDANs) during midbrain development. However, in adulthood, Otx2 is primarily expressed in the ventral tegmental area (VTA)-ventral part, and mDANs in the dorsal part of the VTA and the substantia nigra pars...