Osteoprotective effects of lifestyle interventions against obesity-induced bone dyshomeostasis and bone loss in rats

ABSTRACT: Unhealthy lifestyles and chronic metabolic stress are key contributors to obesity and the increased risk of osteoporotic fractures, both of which are significant global health concerns. This study aimed to evaluate the time-dependent effects of exercise and caloric restriction (CR) on bone homeostasis and quality in high-fat diet (HFD)-induced obesity. Seven-week-old male Wistar rats were fed either a normal diet (ND; n = 6) or an HFD (n = 30) for 28 weeks to induce obesity. At week...