Pyroptosis of periodontal ligament stem cells aggravates periodontitis via Piezo1 channel

Periodontitis is a chronic inflammatory disease that leads to periodontal tissue destruction, but the mechanisms underlying inflammation-induced stem cell dysfunction remain unclear. This study examines the role of Piezo1 in modulating pyroptosis in periodontal ligament stem cells (PDLSCs) during periodontitis. Using a mouse model induced by silk ligatures and in vitro PDLSC stimulation with LPS and nigericin, we found that inflammation activated Piezo1, promoting Ca^(2+) influx and triggering...