Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve caused by loss of primary cilia

pubmed: wnt1 2025-10-07

Summary:

CONCLUSION: These data show that primary cilia, via the Notch-Jag1 signalling pathway, regulate differentiation of SHF cells in the aortic valve primordia. Additionally, we identify a mechanistic link between the developmental basis of quadricuspid and bicuspid arterial valve leaflets.

Link:

https://pubmed.ncbi.nlm.nih.gov/40498626/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20251007010438&v=2.18.0.post9+e462414

From feeds:

Exome » pubmed: wnt1

Authors:

Ahlam Alqahtani, Lorraine Eley, Jake Newton, Kimberley McDonald, Chloe Connolly, Cindy Rodrigues-Cleto, Kristyna Neffeova, Leonor Lopez, Javier Arias, Christopher J Derrick, Mashael Alaradi, Hana Kolesova, Bill Chaudhry, Deborah J Henderson

Date tagged:

10/07/2025, 01:05

Date published:

06/11/2025, 06:00