Concentrations of Adrenocorticotropic Hormone (ACTH<sub>1-24</sub>) Too Low to Effect Cortisol Enhance Osteogenesis <em>In Vitro</em> and <em>In Vivo</em>
pubmed: wnt1 2025-10-07
Summary:
After finding that minimal amounts of adrenocorticotropic hormone (ACTH(1-24)) prevented osteonecrosis in rabbits, we studied bone formation at nanomolar ACTH(1-24), in vivo in rabbits, and in vitro in human osteoblasts. ACTH(1-24) in rabbits at 0.6 μg/kg/day had no measurable effect on cortisol. Groups of five rabbits given 0.6 μg/kg/day of ACTH(1-24) enhanced trabecular bone in the rabbit femoral head relative to saline-treated controls (controls), increased bone volume/total volume (BV/TV) by...