Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits

Patterns of gut motility, such as colonic motor complexes, are controlled by central pattern generators (CPG) in the enteric nervous system; however, the mechanisms that co-ordinate enteric neural networks underlying this behaviour remain unclear. Evidence from similar CPGs in the brain suggests that glia play key roles through mechanisms involving the S100 calcium-binding protein B (S100B). Enteric glia are abundant in enteric neural networks and engage in bi-directional interactions with...