Inhibition of the METTL3/m<sup>6</sup>A/miR-34a-5p axis suppresses trigeminovascular activation in nitroglycerin-induced migraine via the Wnt/β-catenin pathway

pubmed: wnt1 2025-12-10

Summary:

CONCLUSION: METTL3 contributes to migraine pathogenesis through m⁶A-dependent upregulation of miR-34a-5p, which suppresses the Wnt1/β-catenin axis and promotes TGVS activation. Targeting this pathway may offer new therapeutic avenues for migraine.

Link:

https://pubmed.ncbi.nlm.nih.gov/41039196/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20251210113710&v=2.18.0.post22+67771e2

From feeds:

Exome » pubmed: wnt1

Authors:

Hui Zhang, Minming Shao, Feng Zhang, Caiyan He, Jiabi Li, Shengdong He

Date tagged:

12/10/2025, 11:37

Date published:

10/02/2025, 06:00