Treatment With Romosozumab In Progressive Pseudorheumatoid Dysplasia

Progressive pseudorheumatoid dysplasia (PPD) is a rare genetic disorder caused by pathogenic variants in Wnt1-inducible signaling pathway protein 3 gene. The primary skeletal issues include progressive joint stiffness, bone deformities, and bone fragility. Patients with PPD may have a higher risk of fractures resulting from secondary osteoporosis, joint instability, and skeletal weakness. Because PPD is a rare condition with limited specific treatment guidelines, antifracture therapies that are...