IMT504 accelerates post-hepatectomy liver regeneration in mice with involvement of GLAST + Wnt1 + bone marrow stromal progenitors
pubmed: wnt1 2025-12-13
Summary:
The immunomodulatory oligodeoxynucleotide (ODN) IMT504 exhibits antifibrotic and pro-regenerative properties in the context of liver fibrosis. It also enhances the contribution of GLAST^(+) Wnt1^(+) bone marrow stromal progenitors (BMSPs) to liver regeneration in a mouse model of chronic liver disease. In this study, partial hepatectomy (PHx) was performed in CD1 mice. In parallel, Cre-loxP mice were used to identify GLAST^(+) Wnt1^(+) BMSPs and assess their contribution to liver cells...