FZD7 expression marks mammary tumor-initiating cells
pubmed: wnt1 2025-12-14
Summary:
The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoint specific components driving tumor development. Using the MMTV-Wnt1 genetically engineered mouse model, which develops mixed-lineage mammary tumors resembling triple-negative breast cancer and composed of both basal and luminal subtypes, we identify the...