Wnt/β-catenin/ATF3 signaling promotes the progression from acute kidney injury to chronic kidney disease by regulating mitophagy in mice

Sustained activation of Wnt/β-catenin signaling has been shown to promote the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). However, its underlying mechanisms remain largely unclear. In this study, we addressed this question using a unilateral ischemia/reperfusion injury model in mice and a hypoxia/reoxygenation model in HKC-8 cells. In vitro, Wnt1 overexpression disrupted mitochondrial structure, increased the expression of DRP1 and p62, and decreased the levels of...