Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury

CONCLUSIONS: Using cell tracer models, we confirm that adipose-derived neural stem cells can be therapeutically delivered to injured peripheral nerves, integrate with recipient axons and Schwann cells, and differentiate into myelinating Schwann-like cells to enhance motor recovery. These findings indicate that subcutaneous adipose tissue-derived neural stem cells could fill a critical gap in the treatment of peripheral nerve injuries, representing a readily available, autologous source of...