Impact of coding and non-coding SNPs in the FZD8 gene on structural and functional alterations associated with tumorigenesis: A multi-faceted computational approach
pubmed: wnt1 2026-03-04
Summary:
FZD8, a GPCR, is involved in various physiological processes, such as cell differentiation, bone growth and stem cell regulation, by binding to various Wnt ligands. Though FZD receptors have low mutation rates in cancer, aberrant Wnt or FZD expression leads to deregulated Wnt/FZD signaling pathways that may result in tumorigenesis. The structural and functional effects of most of the coding and non-coding SNPs of human FZD8 gene are yet to explore. In the present study, we analyzed 450, 109, and...