Deciphering the dose-dependent nephrotoxic mechanisms of etoxazole: Insights from redox signaling and Wnt/β-catenin axis

Etoxazole (ETZ) is a selective acaricide that is reported to induce severe organ toxicity including renal impairments. The current research was conducted to evaluate the dose-dependent toxic effects of ETZ on renal tissues. Thirty-six male Sprague Dawley rats were divided into control, ETZ (2.2 mg/kg b.w/day), ETZ (11 mg/kg b.w/day), and ETZ (22 mg/kg b.w/day) treated group. It was found that ETZ intoxication upregulated the mRNA expressions of Wnt family member 1 (Wnt1), Wnt family member 4...