Inhibition of H3K14 lactylation promotes diabetic corneal nerve regeneration via Wnt1/beta-catenin signaling
pubmed: wnt1 2026-03-11
Summary:
CONCLUSIONS: Hyperglycemia-driven glycolysis increases lactate-mediated H3K14la at the Wnt1 promoter, repressing Wnt1/β-catenin signaling and impairing corneal nerve regeneration. Targeting lactate metabolism or histone lactylation represents a promising therapeutic strategy for DK.