Traumatic brain injury enhances fracture healing by upregulating VNN1 to activate the Wnt/β-catenin signaling pathway
pubmed: wnt1 2026-07-10
Summary:
CONCLUSIONS: VNN1 is a key factor mediating TBI-induced fracture healing by non-canonically regulating the Wnt/β-catenin signaling pathway to promote osteogenic differentiation and bone tissue maturation. This study provides a novel mechanism for understanding the effects of systemic trauma on local bone repair and offers potential molecular targets for fracture treatment.