Video-based gait analysis for clinical monitoring of genotype-specific functional patterns in osteogenesis imperfecta

CONCLUSIONS: Routine outpatient smartphone videos combined with markerless pose estimation can capture genotype-associated gait patterns in pediatric OI. WNT1-related OI was characterized by a wider base of support and coronal-plane compensation, whereas IFITM5-related OI showed mild longitudinal changes in spatial gait metrics. Video-derived gait parameters may provide low-burden adjunctive measures for outpatient functional monitoring, although prospective reference-standard validation and...