A tissue engineering approach to regenerate the cranial suture skeletal stem cell niche with a multicompartment biomaterial scaffold

Craniosynostosis is a debilitating congenital anomaly characterized by the premature fusion of cranial sutures in the skull, resulting from the abnormal fate specification of critical skeletal stem cells. This leads to disrupted craniofacial development and dysmorphology. As an alternative to invasive cranial vault remodeling surgery, we propose a tissue engineering approach to effectively restore the damaged or absent suture stem cell niche using a biomaterial capable of regioselective stem...