Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule-associated complex requires Pasovec/Gid8 proteins

Wg/Wnt signaling is critical throughout development and homeostasis and associated with many diseases, including cancer. Wg/Wnt signaling is mediated by β-catenin (Armadillo/Arm in Drosophila) with the IFT-A/Kinesin2 complex promoting nuclear translocation of β-catenin/Arm. Existing information suggests that additional proteins are involved. Here, we demonstrate that a conserved protein, Pasovec (Psv; Gid8 in mammals), with loss-of-function mutants resembling wg and arm/β-catenin mutant...