WISP-3 enhances proinflammatory cytokine IL-1β production in rheumatoid arthritis through the FAK, JNK and AP-1 pathways
pubmed: wnt1 2026-07-11
Summary:
CONCLUSION: These in vitro findings indicate that WISP-3 acts as a pro-inflammatory mediator in RA by promoting IL-1β expression primarily through activation of the FAK/JNK/c-Jun pathway, with additional contributions from other signaling pathways.