Deacetylasperulosidic acid methyl ester attenuates liver fibrosis by modulating the SCFAs-Wnt/β-catenin signaling axis
pubmed: wnt1 2026-07-11
Summary:
Liver fibrosis is a common pathological consequence of chronic liver injury, characterized by excessive extracellular matrix deposition, hepatocellular damage and persistent inflammation, which may progress to cirrhosis or hepatocellular carcinoma. Currently, no specific and effective antifibrotic therapies are available. Deacetylasperulosidic acid methyl ester (DAM), a natural iridoid compound derived from Rubiaceae plants, possesses anti-inflammatory and antioxidant properties. However, its...