<em>Codonopsis pilosula</em> polysaccharide attenuates the inflammatory response in macrophages induced by <em>Brucella</em> abortus outer membrane protein 19 via regulating <em>ATP2A1</em> to modulate cell adhesion and calcium signaling
pubmed: wnt1 2026-08-26
Summary:
Brucellosis is a zoonotic disease caused by Brucella species. Its pathogenesis is closely associated with bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumulating evidence indicates that Codonopsis pilosula polysaccharides (CPPS) inhibit inflammatory signaling, enhance macrophage phagocytosis, and exert immunomodulatory effects across multiple organs. However, the therapeutic potential of CPPS in...