WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12

Lung adenocarcinoma (LUAD) is characterized by a high propensity for metastasis and poor clinical outcomes. Although members of the cellular communication network (CCN) family exhibit context-dependent roles in tumor progression, the function of WNT1-inducible signaling pathway protein 3 (WISP-3), also known as CCN6, in LUAD remains incompletely understood. In this study, we demonstrate that WISP-3 is significantly upregulated in LUAD tissues and is associated with unfavorable patient survival....