Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/beta-catenin signaling pathway
pubmed: wnt1 2021-06-23
Summary:
CONCLUSIONS: WNT1 c.110 T>C and c.505G>T mutations may alter the proliferation and osteogenic phenotype of MC3T3-E1 linked to the progression of OI via the inhibition of the WNT1/β-catenin signaling pathway. This is the first study to confirm the effect of WNT1 c.110 T>C and c.505G>T missense mutations on osteoblast differentiation and propose a new molecular mechanism for OI development.