MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer
pubmed: wnt1 2022-03-19
Summary:
Metastatic progression of tumors is driven by genetic alterations and tumor-stroma interaction. To elucidate the mechanism underlying the oncogene-induced gastric tumor progression, we have developed an organoid-based model of gastric cancer from GAstric Neoplasia (GAN) mice, which express Wnt1 and the enzymes COX2 and microsomal prostaglandin E synthase 1 in the stomach. Both p53 knockout (GAN-p53KO) organoids and KRAS^(G12V) -expressing GAN-p53KO (GAN-KP) organoids were generated by genetic...