Electrical Stimulation Therapy and HA/TCP Composite Scaffolds Modulate the Wnt Pathways in Bone Regeneration of Critical-Sized Defects

pubmed: wnt1 2023-01-28


Critical bone defects are the most difficult challenges in the area of tissue repair. Polycaprolactone (PCL) scaffolds, associated with hydroxyapatite (HA) and tricalcium phosphate (TCP), are reported to have an enhanced bioactivity. Moreover, the use of electrical stimulation (ES) has overcome the lack of bioelectricity at the bone defect site and compensated the endogenous electrical signals. Such treatments could modulate cells and tissue signaling pathways. However, there is no study...



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Júlia Venturini Helaehil, Luiza Venturini Helaehil, Laryssa Fernanda Alves, Boyang Huang, Milton Santamaria-Jr, Paulo Bartolo, Guilherme Ferreira Caetano

Date tagged:

01/28/2023, 20:49

Date published:

01/21/2023, 06:00