A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis

pubmed: wnt1 2023-01-28

Summary:

Fibrosis is the major risk factor associated with morbidity and mortality in patients with non-alcoholic steatohepatitis (NASH)-driven chronic liver disease. Although numerous efforts have been made to identify the mediators of the initiation of liver fibrosis, the molecular underpinnings of fibrosis progression remain poorly understood, and therapies to arrest liver fibrosis progression are elusive. Here, we identify a pathway involving WNT1-inducible signaling pathway protein 1 (WISP1) and...

Link:

https://pubmed.ncbi.nlm.nih.gov/35987202/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230128221328&v=2.17.9.post6+86293ac

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Exome ยป pubmed: wnt1

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Authors:

Ying Xi, Ryan LaCanna, Hsiao-Yen Ma, Elsa-Noah N'Diaye, Sarah Gierke, Patrick Caplazi, Meredith Sagolla, Zhiyu Huang, Laura Lucio, Alexander Arlantico, Surinder Jeet, Hans Brightbill, Claire Emson, Aaron Wong, Katrina B Morshead, Daryle J DePianto, Merone Roose-Girma, Charles Yu, Lucinda Tam, Guiquan Jia, Thirumalai R Ramalingam, Scot Marsters, Avi Ashkenazi, Si Hyun Kim, Ryan Kelly, Shuang Wu, Paul J Wolters, Ariel E Feldstein, Jason A Vander Heiden, Ning Ding

Date tagged:

01/28/2023, 22:13

Date published:

08/20/2022, 06:00