Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease

pubmed: wnt1 2023-01-29

Summary:

Wnt and R-spondin (Rspo) proteins are two major types of endogenous Wnt/β-catenin signaling agonists. While Wnt/β-catenin signaling is greatly diminished in Alzheimer's disease (AD), it remains to be elucidated whether the inhibition of this pathway is associated with dysregulation of Wnt and Rspo proteins. By analyzing temporal cortex RNA-seq data of the human postmortem brain samples, we found that WNT1 and RRPO2 were significantly downregulated in human AD brains. In addition, the expression...

Link:

https://pubmed.ncbi.nlm.nih.gov/36215026/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&fc=None&ff=20230129014240&v=2.17.9.post6+86293ac

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Authors:

Jesse R Macyczko, Na Wang, Jing Zhao, Yingxue Ren, Wenyan Lu, Tadafumi C Ikezu, Na Zhao, Chia-Chen Liu, Guojun Bu, Yonghe Li

Date tagged:

01/29/2023, 01:42

Date published:

10/10/2022, 06:00